Anticancer drug resistance in drug‐induced cell death of U937 cells

Altruistic cell death and collective drug resistance

The Greek myth of Castor and Pollux is a tale about altruism between brothers. Castor and Pollux were twins but they had different fathers. As a son of the god Zeus, Pollux was immortal, but Castor whose father was human, eventually died. Pollux could not bear grief and asked Zeus to share his immortality with his brother or even to give it away and join him in death. Moved by Pollux’s altruism...

Regulated Cell Death: Apoptosis and Necroptosis in U937 Cell Line

Coxsackievirus B3 protease 3C induces cell death in eukaryotic cells

Abstract: Coxsackievirus B3 (CVB3) is the most common agent known to cause viral myocarditis. The viral genome encodes a single polyprotein that is cleaved to produce several proteins by virally encoded proteases. Most of this proteolytic processing is catalyzed by a cysteine protease called 3C. The 3C protease plays major role in viral replication and cellular damage. To understand the mecha...

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tumors, since its expression confers resistance to doxorubicin and to other chemotherapeutic drugs. In this study, we show that Sorcin is able to bind doxorubicin, vincristine, paclitaxel and cisplatin directly and with high affinity. The high affinity binding of doxorubicin to sorcin has been demo...

Modelling cell death in human tumour cell lines exposed to the anticancer drug paclitaxel.

Most anti-cancer drugs in use today exert their effects by inducing a programmed cell death mechanism. This process, termed apoptosis, is accompanied by degradation of the DNA and produces cells with a range of DNA contents. We have previously developed a phase transition mathematical model to describe the mammalian cell division cycle in terms of cell cycle phases and the transition rates betw...